Invitrogen™ HHV-1 US3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA567986

Product Code. 15892984

Description

HHV-1 US3 Polyclonal Antibody for Western Blot

US3 is a multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of apoptosis. It phosphorylates UL31 and UL34, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress. US3 modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3. It also phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface, and promotes virus intracellular spread by restructuring host cell cytoskeleton. US3 blocks host apoptosis to extend cell survival and allow efficient viral replication. Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing.

Specifications

• Antigen: HHV-1 US3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide; pH 7.4
• Immunogen: Synthesized peptide derived from human KR1_HHV11.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Form: Liquid