Invitrogen™ HGS Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA595931

Product Code. 16558771

Description

Immunogen sequence: EQQKQTVQMR AQMPAFPLPY AQLQAMPAAG GVLYQPSGPA SFPSTFSPAG SVEGSPMHGV YMSQPAPAAG PYPSMPSTAA DPSMVSAYMY PAGATGAQAA PQAQAGPTAS PAYSSYQPTP TAGYQNVASQ APQSLPAISQ PPQSSTMGYM GSQSVSMGYQ PYNMQNLMTT LPSQDASLPP QQPYIAGQQP MYQQMAPSGG PPQQQPPVAQ QPQAQGPPAQ GSEAQLISFD; Positive Samples: THP-1, OVCAR3, MCF7, HepG2, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Cytoplasmic side, Early endosome membrane, Endosome, Peripheral membrane protein, multivesicular body membrane.

HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.

Specifications

• Antigen: HGS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HGS
• Gene Alias: hepatocyte growth factor-regulated tyrosine kinase substrate; HGF-regulated tyrosine kinase substrate; HGNC:4897; Hgr; Hgs; Hrs; Hrs2; human growth factor-regulated tyrosine kinase substrate; protein pp110; SNAP-25-interacting protein Hrs-2; ZFYVE8
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15239, 56084, 9146
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.11 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O14964, Q99LI8, Q9JJ50
• Gene Symbols: HGS
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 548-777 of human HGS (NP_0047031).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG