Invitrogen™ HERC5 Monoclonal Antibody (K29053_10C7), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA555920

Product Code. 30203984

Description

Sequence of this protein is as follows: RESEFALRPT FDLTVRRNHL IEDVLNQLSQ FENEDLRKEL WVSFSGEIGY DLGGVKKEFF YCLFAEMIQP EYGMFMYPEG ASCMWFPVKP KFEKKRYFFF GVLCGLSLFN CNVANLPFPL ALFKKLLDQM PSLEDLKELS PDLGKNLQTL LDDEGDNFEE VFYIHFNVHW DRNDTNLIPN GSSITVNQTN KRDYVSKYIN YIFNDSVKAV YEEFRRGFYK MCDEDIIKLF HPEELKDVIV GNTDYDWKTF EKNARYEPGY NSSHPTIVMF WKAFHKLTLE EKKKFLVFLT GTDRLQMKDL NNMKITFCCP ESWNERDPIR ALTCFSVLFL PKYSTMETVE EALQEAINNN

HERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 conjugation. It acts a positive regulator of innate antiviral response in cells induced by interferon. HERC5 functions as a part of the ISGylation machinery that recognizes target protein in a broad and relatively non-specific manner. It catalyzes ISGylation of IRF3 - which results in sustained activation, it attenuates IRF3-PIN1 interaction - which antagonizes IFR3 ubiquitination and degradation, and boosts the antiviral repsonse. HERC5 is physically assocated with polyribosomes and broadly modifies newly synthesized proteins in a cotranslational manner.

Specifications

• Antigen: HERC5
• Classification: Monoclonal
• Concentration: 0.67 mg/mL
• Formulation: PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide
• Gene Accession No.: Q9UII4
• Gene Symbols: HERC5
• Immunogen: Recombinant human HERC5 (immunogen range is 671-1020).
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: K29053_10C7
• Conjugate: Unconjugated
• Gene: HERC5
• Gene Alias: CEB1; CEBP1; Cyclin-E-binding protein 1; E3 ISG15--protein ligase HERC5; HECT and RLD domain containing E3 ubiquitin protein ligase 5; HECT domain and RCC1-like domain-containing protein 5; hect domain and RLD 5; HERC5; probable E3 ubiquitin-protein ligase HERC5
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 51191
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid