Invitrogen™ Hepsin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA530062

Product Code. 13424597

Description

Recommended positive controls: A431, HeLa. Predicted reactivity: Mouse (91%), Rat (91%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Hepsin, encoded by the HPN gene, is a type II transmembrane serine protease prominently expressed in tissues such as the liver, kidney, and prostate. Hepsin plays a crucial role in proteolytic processes involved in extracellular matrix remodeling, cell growth, and development. It is known for activating precursor molecules, including hepatocyte growth factor (HGF), which is essential for liver development and regeneration. Furthermore, hepsin's involvement extends to influencing cell signaling pathways related to tissue homeostasis and repair. In the context of cancer, particularly prostate cancer, hepsin is implicated in tumor progression and metastasis by promoting extracellular matrix degradation, thereby facilitating tumor invasion and spread. Aberrant expression or activity of hepsin is associated with pathophysiological changes in the tumor microenvironment, making it a target for therapeutic interventions aimed at controlling cancer progression. Research continues to explore hepsin's biochemical functions and regulatory mechanisms, providing insights into its potential roles in both normal physiology and disease states.

Specifications

• Antigen: Hepsin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HPN
• Gene Alias: hepsin; hepsin (transmembrane protease, serine 1); Hlb320; HPN; Serine protease hepsin; Serine protease hepsin catalytic chain; Serine protease hepsin non-catalytic chain; testicular tissue protein Li 85; TMPRSS1; Transmembrane protease serine 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3249
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.77 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P05981
• Gene Symbols: HPN
• Immunogen: Recombinant protein encompassing a sequence within the Extracellular domain of human Hepsin. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG