Invitrogen™ Hemoglobin alpha Recombinant Rabbit Monoclonal Antibody (PD00-16)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA550713

Product Code. 17920613

Description

Positive control: Rat heart tissue lysates, human bone marrow tissue, human liver tissue, human placenta tissue, mouse brain tissue, human spleen tissue. Predicted band size: 15 kDa Subcellular Location: Cytosol, cytosolic small ribosomal subunit, hemoglobin complex, blood microparticle, extracellular exosome, extracellular region, extracellular space, endocytic vesicle lumen, haptoglobin-hemoglobin complex, membrane.

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.

Specifications

• Antigen: Hemoglobin alpha
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P01942, P01946, P69905
• Gene Symbols: Hba, Hba-a1, Hba1
• Immunogen: Synthetic peptide corresponding to Human Hemoglobin subunit alpha aa 50-150/142.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: PD00-16
• Conjugate: Unconjugated
• Gene: Hba1
• Gene Alias: alpha 1 globin; alpha globin 1; alpha one globin; alpha-1/2-globin; alpha-2 globin chain; alpha-globin; delta globin; GloA; globin, alpha; haemaglobin alpha 1; Hba; HBA1; HBA2; Hba-a1; Hba-a2; HBAM; Hbat1; HBA-T3; HBH; hemoglobin alpha 1 chain; hemoglobin alpha 1 globin chain; hemoglobin alpha chain; hemoglobin alpha, adult chain 1; hemoglobin alpha, adult chain 2; hemoglobin alpha-1/2 chain; Hemoglobin subunit alpha; hemoglobin subunit alpha 1; hemoglobin subunit alpha-1/2; hemoglobin, alpha 1; LOC287167
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 15121, 15122, 25632, 287167, 3039
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid