Invitrogen™ HDAC5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA583172

Product Code. 16310135

Description

Immunogen sequence: THPEETEEEL TEQQEVLLGE GALTMPREGS TESESTQEDL EEEDEEDDGE EEEDCIQVKD EEGESGAEEG PDLEEPGAGY KKLFSDAQP Highest antigen sequence indentity to the following orthologs: Mouse - 85%, Rat - 84%.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: HDAC5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HDAC5
• Gene Alias: AI426555; Antigen NY-CO-9; DKFZp779K1053; FLJ90614; HD5; HD7; HD7b; HD9; HDAC; Hdac4; HDAC5; HDAC-5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; histone deacetylase 4; histone deacetylase 5; histone deacetylase mHDA1; KIAA0600; KIAA0744; mHDA1; mKIAA0600; NY-CO-9
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10014
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UQL6
• Gene Symbols: HDAC5
• Immunogen: Recombinant protein corresponding to Human HDAC5. Recombinant protein control fragment (Product #RP-95274).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG