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  6. HDAC3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

HDAC3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16876523 Shop All Proteintech Products
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150 μL
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Product Code. 16876523 Supplier Proteintech Supplier No. 102551AP20UL

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Description

Rabbit Polyclonal Antibody

This antibody is a rabbit polyclonal antibody raised against an internal region of human HDAC3.

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 ′Lys-27′ (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (By similarity).

Specifications

Antigen HDAC3
Applications Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.27 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene HDAC3
Gene Accession No. O15379, O88895, Q6P6W3
Gene Alias HD3, HDAC3, histone deacetylase 3, RPD3, RPD3 2, SMAP45
Gene Symbols Hdac3
Host Species Rabbit
Immunogen HDAC3 Fusion Protein Ag0396
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15183, 84578, 8841
Target Species Human, Rat, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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