Invitrogen™ HDAC1 Polyclonal Antibody, Alexa Fluor™ 647

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA1860A647

Product Code. 15977284

Description

PA1860A647 detects histone deacetylase 1 (HDAC1) from human, mouse, rat, hamster and canine tissues and cells. The PA1860A647 immunogen is a synthetic peptide corresponding to residues C E(467) E K P E A K G V K E E V K L A(482) of human HDAC1. This immunizing peptide (Cat. # PEP-069) is available for use in neutralization and control experiments.

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.

Specifications

• Antigen: HDAC1
• Classification: Polyclonal
• Conjugate: Alexa Fluor 647
• Gene: HDAC1
• Gene Alias: DKFZp686H12203; GON-10; HD1; Hdac1; Hdac1-ps; Histone deacetylase 1; histone deacetylase 1-like protein; MommeD5; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2; RPD3; RPD3L1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100752721, 297893, 3065, 433759, 487309
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O09106, Q13547, Q4QQW4
• Gene Symbols: HDAC1
• Immunogen: Synthetic peptide corresponding to residues C E(467) E K P E A K G V K E E V K L A(482) of human HDAC1.
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Hamster
• Product Type: Antibody
• Isotype: IgG