Invitrogen™ HCN4 Monoclonal Antibody (SHG 1E5)

Rat Monoclonal Antibody

Brand:  Invitrogen™ MA3903

Product Code. 11535792

Description

MA3-903 detects HCN4 from human, mouse, and rat samples. MA3-903 has been successfully used in Western blotting and immunohistochemistry procedures. By Western blot MA3-903 detects a ~132 KDa band representing HCN4. The MA3-903 immunogen is a synthetic peptide sequence corresponding to residues S H G S L L L P P A S S P P P P Q V P Q R R G T P P L T P G R L T Q D L K L of HCN4. MA3-903 clone SHG 1E5 is a rat monoclonal hybridoma. This antibody was produced by immunizing a rat, isolating the spleen cells, creating the hybridoma and successively injecting these cells into a mouse to produce ascites.

HCN4 is a member of the family of hyperpolarization-activated and cyclic-nucleotide-gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node.

Specifications

• Antigen: HCN4
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.05% sodium azide
• Gene Accession No.: O70507, Q9JKA7, Q9Y3Q4
• Gene Symbols: Hcn4
• Immunogen: Synthetic peptide sequence corresponding to residues S H G S L L L P P A S S P P P P Q V P Q R R G T P P L T P G R L T Q D L K L of HCN4.
• Regulatory Status: RUO
• Gene ID (Entrez): 10021, 330953, 59266
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Clone: SHG 1E5
• Conjugate: Unconjugated
• Gene: Hcn4
• Gene Alias: Bcng3; BCNG-3; brain cyclic nucleotide-gated channel 3; Hcn3; Hcn4; hyperpolarization activated cyclic nucleotide gated potassium channel 4; hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; hyperpolarization-activated, cyclic nucleotide-gated K+ 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; SSS2
• Host Species: Rat
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1