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Invitrogen™ HAS2 Monoclonal Antibody (4E7)
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Product Code. 15235166
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Quantity:
100 μg
Unit Size:
100µg
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15235166 100 μg 100µg
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Product Code. 15235166 Supplier Invitrogen™ Supplier No. MA517087

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Description

Mouse Monoclonal Antibody

MA5-17087 targets HAS2 in indirect ELISA, ICC, IHC, IF and WB applications and shows reactivity with Human samples. The MA5-17087 immunogen is purified recombinant fragment of human HAS2 (amino acids: 67-170) expressed in E. Coli. MA5-17087 detects HAS2 which has a predicted molecular weight of approximately 63.5kDa.

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HAS2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 4E7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene HAS2
Gene Accession No. Q92819
Gene Alias HA synthase 2; Has2; Hyaluronan synthase 2; hyaluronan synthase homolog; Hyaluronan synthase type 2; hyaluronate synthase 2; Hyaluronic acid synthase 2
Gene Symbols HAS2
Host Species Mouse
Immunogen Purified recombinant fragment of human HAS2 (amino acids: 67-170) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3037
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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