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Invitrogen™ HAP1 Polyclonal Antibody

Product Code. 12838562
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12838562 100 μg 100µg
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Product Code. 12838562 Supplier Invitrogen™ Supplier No. PA520377

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse brain tissue lysate. PA5-20377 can be used with blocking peptide PEP-0494.

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HAP1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene HAP1
Gene Accession No. O35668, P54256, P54257
Gene Alias Hap1; HAP-1; HAP-1 antibody; HAP1-A; HAP1-B; HAP2; hHLP1; HIP5; HLP; HLP1; huntingtin associated protein 1; huntingtin-associated protein 1; huntingtin-associated protein 2; neuroan 1
Gene Symbols HAP1
Host Species Rabbit
Immunogen A 19 amino acid peptide from near the center of human HAP1.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15114, 29430, 9001
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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