Invitrogen™ HACE1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5103812

Product Code. 16630265

Description

Antibody detects endogenous levels of total HACE1.

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

Specifications

• Antigen: HACE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HACE1
• Gene Alias: 1700042J16Rik; A730034A22Rik; BC025474; E3 ubiquitin-protein ligase HACE1; hace 1; Hace1; HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1; HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1; KIAA1320; SPPRS
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 209462, 361866, 57531
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: D3ZBM7, Q3U0D9, Q8IYU2
• Gene Symbols: HACE1
• Immunogen: A synthesized peptide derived from human HACE1(Accession Q8IYU2), corresponding to amino acid residues D777-E827.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG