Invitrogen™ H2A.Zac pan-acetyl (K4,K7,K11,K13) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5114690

Product Code. 17257453

Description

Antibody detects endogenous levels of Acetyl-H2A.Z only when acetylated at Lys4/7/11/13.

H2A.Zac pan-acetyl (K4,K7,K11,K13) is classified under histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Specifications

• Antigen: H2A.Zac pan-acetyl (K4,K7,K11,K13)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: H2AFZ
• Gene Alias: H2A histone family member Z; H2A histone family, member Z; H2A.z; H2a.z-1; H2A/z; H2AFZ; H2az; H2AZ histone; histone H2A.Z
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3015
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P0C0S5
• Gene Symbols: H2AFZ
• Immunogen: A synthesized peptide derived from human H2AFZ(Accession P0C0S5), corresponding to amino acid residues M1-S21.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG