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  5. Tocris Bioscience™ GW 5074

Tocris Bioscience™ GW 5074
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Product Code. 18075962
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18075962

Brand: Tocris Bioscience™ 1381/50

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This item is not returnable. View return policy

Description

Potent, selective c-Raf1 kinase inhibitor

GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). GW 5074 displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW 5074 binds mutant huntingtin (mHTT) and decreases levels of mHTT in cultured hippocampal neurons and fibroblasts from patients with Huntington's disease. Brain penetrant.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 220904-83-6
Molecular Formula C15H8Br2INO2

Specifications

Quantity 50 mg
Formula Weight 520.94
Purity >98%
Molecular Weight (g/mol) 520.95
Chemical Name or Material GW 5074
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