Invitrogen™ Guselkumab Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30283703	Invitrogen™ MA558657	100 μg
30283069	Invitrogen™ MA558658	1 mg

Description

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Guselkumab is a human immunoglobulin G1 lambda (IgG1lambda) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation 2. In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in dermatological manifestations of psoriasis. Developed by Janssen, the subcutaneous injection form of guselkumab was approved in July 2017 under the market name Tremfya for the treatment of adult patients with moderate-to-severe plaque psoriasis.

Specifications

• Antigen: Guselkumab
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Lyophilized
• Isotype: IgG1
• Target Species: Human
• Gene Alias: CNTO-1959
• Product Type: Antibody

• Concentration: 1 mg/mL
• Applications: ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
• Conjugate: Unconjugated
• Host Species: Human
• Regulatory Status: RUO
• Formulation: 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
• Primary or Secondary: Primary
• Purification Method: Protein A