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Description
- Guanidine Hydrochloride is a strong chaotropic agent useful for the denaturation and subsequent refolding of proteins
- This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies and be used for the recovery of periplasmic proteins
- This can be used as the first step in refolding proteins or enzymes into their active form
- Urea and dithiothreitol (DTT) may also be necessary
- It is also used in the isolation of RNA to dissociate the nucleoprotein into its nucleic acid and protein moieties
- It is an inhibitor of RNase
Specifications
Specifications
| CAS | 50-01-1 |
| Melting Point | 175°C to 190°C |
| Color | White |
| Molecular Formula | CH6ClN3 |
| Linear Formula | CH5N3·HCl |
| MDL Number | MFCD00013026 |
| Quantity | 250 g |
| Synonym | guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochloride |
| Solubility Information | Soluble in (6M aq soln): Relatively Clear to Cloudy Yellow Solution with Sediment on Standing. |
| InChI Key | PJJJBBJSCAKJQF-UHFFFAOYSA-N |
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Safety and Handling
Product Identifier
- Guanidine Hydrochloride, practical grade
- Warning
- Acute toxicity Category 4
- Serious eye damage/eye irritation Category 2
- Skin corrosion/irritation Category 2
- H302-Harmful if swallowed.
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- P101-If medical advice is needed, have product container or label at hand.
- P102-Keep out of reach of children.
- P103-Read label before use.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P321-Specific treatment (see on this label).
- P332+P313-If skin irritation occurs: Get medical advice/attention.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
- MIXTURE LIST-Contains : Guanidine Hydrochloride
Product Title
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