Invitrogen™ GTPBP4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA585296

Product Code. 16362235

Description

Keep as concentrated solution. Predicted reactivity: Mouse (91%), Rat (91%), Chicken (83%), Bovine (89%). Positive Control: 293T, A431, HeLa, HepG2, Neuro 2A, GL261, C8D30, NIH-3T3, BCL-1, C2C12, PC-12, Rat2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.

Specifications

• Antigen: GTPBP4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gtpbp4
• Gene Alias: 2610028C09Rik; chronic renal failure gene protein; chronic renal failure protein; Crfg; fi28d07; FLJ10686; FLJ10690; FLJ39774; G protein-binding protein CRFG; GTP binding protein 3; GTP binding protein 4; GTP binding protein NGB; GTP-binding protein NGB; Gtpbp3; Gtpbp4; NGB; Nog1; nucleolar GTP-binding protein 1; Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB); Unknown (protein for IMAGE:7956347); wu:fi28d07; zgc:55757
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114300, 23560, 69237
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q99ME9, Q99P77, Q9BZE4
• Gene Symbols: Gtpbp4
• Immunogen: Recombinant protein encompassing a sequence within the center region of human GTPBP4. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG