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Eurofins DiscoverX GSK3α Protein, Active
Description
Glycogen synthase kinase 3 (GSK3) is a protein kinase that was originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism. There exists two isoforms of GSK3, GSK3A and GSK3B, and they are strictly regulated via phosphorylation. GSK3 has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor-1 (HSF-1), and cyclin D1. GSK3A also has been inhibited by activation of the canonical Wnt pathway, resulting in increased catenin that drives human mesenchymal stem cells to osteoblasts.
GenBank NM_019884. The recombinant GSK3a sequence deviates from that published in NM_019884 by a single amino acid substitution, S449A. This substitution has been reported elsewhere,GenBank 2641993.
Specifications
Specifications
| Formulation | mg/mL of enzyme in 50 mM Tris/HCl, pH 7.5, 270 mM sucrose, 0.1 mM EGTA, 150 mM NaCl, 1 mM benzamidine, 0.03% Brij-35, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Molecular Weight (g/mol) | 55 kDa |
| Quantity | 250 μg |
| Species | Human |
| Recombinant | Recombinant |
| Protein Tag | N-terminal 6His |
| Expression System | Recombinant enzyme expressed in Sf21 insect cells |
| Protein Form | Truncated |
| Purity or Quality Grade | ≥50% |
| Protein | GSK-3a, active |
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