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GSK-J4, MedChemExpress

Product Code. 16472797
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 16472797

Brand: Medchem Express HY15648B

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Description

MedChemExpress GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable prodrug of GSK-J1. GSK-J4 induces endoplasmic reticulum stress-related apoptosis.

GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable prodrug of GSK-J1. GSK-J4 induces endoplasmic reticulum stress-related apoptosis.

Specifications

Chemical Name or Material GSK-J4
Physical Form Oil
CAS 1373423-53-0
Color Yellow
Quantity 50 mg
Purity Grade Notes Research
Molecular Formula C24H27N5O2
For Use With (Application) Cancer-programmed cell death
Solubility Information DMSO : ≥ 36 mg/mL (86.23 mM)
SMILES O=C(OCC)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1
Molecular Weight (g/mol) 417.5
Formula Weight 417.5
Percent Purity 95.0%
Grade Research
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Research purposes only

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