GSK-J4, MedChemExpress

Product Code. 16472797

Brand: Medchem Express HY15648B

Description

MedChemExpress GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable prodrug of GSK-J1. GSK-J4 induces endoplasmic reticulum stress-related apoptosis.

GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable prodrug of GSK-J1. GSK-J4 induces endoplasmic reticulum stress-related apoptosis.

Specifications

• Chemical Name or Material: GSK-J4
• Physical Form: Oil
• CAS: 1373423-53-0
• Color: Yellow
• Quantity: 50 mg
• Purity Grade Notes: Research
• Molecular Formula: C₂₄H₂₇N₅O₂
• For Use With (Application): Cancer-programmed cell death
• Solubility Information: DMSO : ≥ 36 mg/mL (86.23 mM)
• SMILES: O=C(OCC)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1
• Molecular Weight (g/mol): 417.5
• Formula Weight: 417.5
• Percent Purity: 95.0%
• Grade: Research

Research purposes only