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Tocris Bioscience™ GSK 329

Product Code. 30000020
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Quantity:
10 mg
Unit Size:
10mg
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30000020 10 mg 10mg
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Product Code. 30000020 Supplier Tocris Bioscience™ Supplier No. 7637/10

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222.70 GBP valid until 2026-03-31
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Description

Potent and selective TNNI3K inhibitor, orally bioavailable

GSK 329 is a potent and selective TNNI3K (cardiac troponin I-interacting kinase) inhibitor (IC50 = 10 nM). It exhibits selectivity for TNNI3K over human VEGFR2 (40-fold), p38α (80-fold), B-Raf (>200-fold) and displays >100-fold selectivity over 80% of 185 kinases tested. In vivo, GSK 329 reduces infarct size, ROS levels, and p38 activation in a mouse model of ischemia/reperfusion cardiac injury. This compound is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-[3,5-Dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]urea
CAS 1268490-12-5
Quantity 10 mg
Target MAPK Inhibitors
Molecular Formula C19H14Cl2F3N5O2
Purity 0.98
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