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Tocris Bioscience™ GSK 126
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Product Code. 18787606
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5 mg
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Product Code. 18787606 Supplier Tocris Bioscience™ Supplier No. 6790/5

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Description

Very high affinity and selective EZH2 inhibitor

GSK 126 is a very high affinity and selective EZH2 inhibitor (Ki = 0.5 - 3 nM). Exhibits >150-fold selectivity for EZH2 over EZH1 and >1000-fold selectivity over 20 other human methyltransferases. Inhibits proliferation of B-cell lymphoma cell lines in vitro. Also inhibits H3K27Me3 and tumor growth in mice bearing BCL xenografts. Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection. Promotes the transition of ESCs to feeder-free extended pluripotent stem (EPS) cells in combination with LCDM cocktail .
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Specifications

Chemical Name or Material N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
CAS 1346574-57-9
Quantity 5 mg
Molecular Formula C31H38N6O2
Formula Weight 526.67
Product Type Inhibitor
Purity 98%
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