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Tocris Bioscience™ GS 441524

Product Code. 18717576
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18717576 10 mg 10mg
18766916 50 mg 50mg
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Product Code. 18717576 Supplier Tocris Bioscience™ Supplier No. 7227/10

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121.60 GBP valid until 2026-03-31
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Description

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide

GS 441524 is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and broad spectrum antiviral nucleotide; active metabolite of Remdesivir (Cat. No. 7226). Competes with natural nucleoside triphosphates, blocking viral RNA synthesis. Exhibits antiviral activity against viruses from Coronaviridae family including SARS-CoV-2 in vitro, and SARS-CoV and feline infectious peritonitis virus (FIPV) in vitro and in vivo. Inhibits SARS-CoV and MERS-CoV- infected HAE cultures (EC50 values are 0.18 and 0.86 μM, respectively) and inhibits murine hepatitis virus (MHV) (EC50 = 1.1 μM).
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (2 R,3 R,4 S,5 R)-2-(4-Aminopyrrolo[2,1-f][1,2,4 ]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
CAS 1191237-69-0
Quantity 10 mg
Target RNA/DNA Polymerase Inhibitors
Molecular Formula C12H13N5O4
Purity 0.98
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