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  6. GRIN2B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

GRIN2B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16811475 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
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16811475 20 μL 20µL
16801475 150 μL 150µL
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Product Code. 16811475 Supplier Proteintech Supplier No. 219201AP20UL

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Description

Rabbit Polyclonal Antibody

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer′s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal domit 6-related mental retardation.

Specifications

Antigen GRIN2B
Applications Immunofluorescence, Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry, Immunoprecipitation
Classification Polyclonal
Concentration 0.38 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene GRIN2B
Gene Accession No. Q00960, Q01097, Q13224
Gene Alias GluN2B, GRIN2B, hNR3, NMDAR2B, NR2B, NR3
Gene Symbols GRIN2B
Host Species Rabbit
Immunogen GRIN2B Fusion Protein Ag16318
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14812, 24410, 2904
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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