GRIK5 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA520451

Product Code. 12828632

Description

A suggested positive control is human brain tissue lysate. PA5-20451 can be used with blocking peptide PEP-0568.

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.

Specifications

• Antigen: GRIK5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GRIK5
• Gene Alias: EAA2; Excitatory amino acid receptor 2; GluK5; GluR gamma-2; GluRgamma2; glutamate ionotropic receptor kainate type subunit 5; glutamate receptor; glutamate receptor gamma-2; Glutamate receptor ionotropic, kainate 5; glutamate receptor KA2; glutamate receptor KA-2; glutamate receptor, ionotropic kainate 5; glutamate receptor, ionotropic, kainate 5; glutamate receptor, ionotropic, kainate 5 (gamma 2); GRIK2; GRIK5; iGlu5; KA2; LOW QUALITY PROTEIN: glutamate receptor ionotropic, kainate 5; MGC128958 protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14809, 24407, 2901
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q16478, Q61626, Q63273
• Gene Symbols: GRIK5
• Immunogen: A 17 amino acid peptide near the carboxy terminus of the human Grik5.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG