Invitrogen™ Grancalcin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA557125

Product Code. 15765021

Description

Immunogen sequence: ALNAWKENFM TVDQDGSGTV EHHELRQAIG LMGYRLSPQT LTTIVKRYSK NGRIFFDDY Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.

This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.

Specifications

• Antigen: Grancalcin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gca
• Gene Alias: 5133401E04Rik; AI573844; Gca; GCL; grancalcin; grancalcin, EF-hand calcium binding protein; grancalcin, EF-hand calcium-binding protein; grancalcin, penta-EF-hand protein; null
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25801
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P28676
• Gene Symbols: Gca
• Immunogen: Recombinant protein corresponding to Human Grancalcin. Recombinant protein control fragment (Product #RP-96011).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG