GRAMD4 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 24299-1-AP-20UL

Product Code. 16882775

Description

GRAMD4 also termed as Death inducing protein is a 578 amino-acid protein, which contains 1 GRAM domain. GRAMD4 as a multi-pass membrane protein localizes in the Mitochondrion membrane. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly (ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows up-regulation in mitochondria by E2F-1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.

Specifications

• Antigen: GRAMD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GRAMD4
• Gene Alias: dA59H18.1, Death inducing protein, DIP, GRAM domain containing 4, GRAMD4, KIAA0767
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23151
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.59 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q6IC98
• Gene Symbols: GRAMD4
• Immunogen: GRAMD4 Fusion Protein Ag19140
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG