Invitrogen™ GPR77 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA532840

Product Code. 13474509

Description

Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon (95%); Monkey (85%); Marmoset (80%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

C5AR2 is an orphan member that belongs to anaphylatoxin receptor family. It is a seven transmembrane G-protein-coupled receptor consisting of an N-terminal N-glycosylation site, several conserved cysteines and several potential C-terminal phosphorylation sites. It binds to C5a and C5a-des-Arg and serves as a highly regulated scavenger receptor with a negative modulatory influence on C5aR-mediated inflammation. Northern Blot analysis suggests it is co- expressed along with C5aR in different tissues and cells including neutrophils/macrophages, mast cells, dendritic cells, brain, lung, heart, kidney, liver, ovary and testis.

Specifications

• Antigen: GPR77
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C5AR2
• Gene Alias: C5a anaphylatoxin chemotactic receptor 2; C5a anaphylatoxin chemotactic receptor C5L2; C5AR2; C5L2; Complement component 5a receptor 2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; GPF77; GPR77; G-protein coupled receptor 77
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27202
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q9P296
• Gene Symbols: C5AR2
• Immunogen: Synthetic 20 amino acid peptide from N-terminal extracellular domain of human C5L2.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG