Invitrogen™ GPR68 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA532836

Product Code. 13424509

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat (100%); Mouse, Bat, Dog, Hamster, Panda, Horse, Pig (94%); Bovine, Rabbit, Platypus (89%); Elephant (83%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.

Specifications

• Antigen: GPR68
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPR68
• Gene Alias: BB131428; Brgr1; Brgrb; G protein-coupled receptor 68; GPR12A; Gpr68; G-protein coupled receptor 68; Ogr1; OGR-1; ovarian cancer G protein-coupled receptor, 1; ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 314386, 8111
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q15743
• Gene Symbols: GPR68
• Immunogen: Synthetic 18 amino acid peptide from 1st extracellular domain of human GPR68.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG