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  6. Invitrogen™ GPR182 Recombinant Rabbit Monoclonal Antibody (K01_1R92)

Invitrogen™ GPR182 Recombinant Rabbit Monoclonal Antibody (K01_1R92)

Product Code. 30825821
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30825821 50 μL
30827111 100 μL
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Product Code. 30825821 Supplier Invitrogen™ Supplier No. MA565233

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Description

Rabbit Recombinant Monoclonal Antibody

GPR182 Recombinant Monoclonal Antibody for Western Blot

Adrenomedullin (ADM) is a hypotensive peptide that belongs to a peptide superfamily, which includes the calcitonin gene-related peptide (CGRP) and amylin. ADM was originally identified in the adrenal medulla, where it is highly expressed. It is also produced by most contractile cells and is upregulated during sepsis and ischemia. Three distinct receptors have the ability to bind ADM and are designated ADM receptor (also designated L1), RDC-1 and the Calcitonin Receptor-Like Receptor (CRLR). The CRLR associates with receptor activity-modifying proteins (RAMPs), which determine the specificity of CRLR binding. Co-expression with RAMP1 results in CRLR binding to CGRP, whereas association with RAMP2 or 3 results in ADM binding. The ADM receptor, a seven transmembrane G protein-coupled receptor, specifically binds ADM and is highly expressed in heart, brain, skeletal muscle, the immune system, adrenal gland and liver. The ADM receptor mediates the signals produced by ADM through G proteins, which activate adenylate cyclase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GPR182
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_1R92
Concentration 1.4 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 0.05% BSA, 150mM NaCl and 0.01% sodium azide; pH 7.4
Gene GPR182
Gene Accession No. O15218, P31392, P43142
Gene Alias 7TMR; ADMR; adrenomedullin receptor; AMR; AM-R; G protein-coupled receptor 182; G10D; G10-D; gamrh; Gpcr17; Gpcr22; GPR182; G-protein coupled receptor 182; HAMR; hrhAMR; MB10; NOW; RAMR
Gene Symbols GPR182
Host Species Rabbit
Immunogen Recombinant protein of human GPR182.
Purification Method Affinity chromatography
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11318, 11536, 29307
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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