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  6. Invitrogen™ GPR109 Monoclonal Antibody (4NZBRGO), Alexa Fluor™ 647, eBioscience™, Invitrogen™

Invitrogen™ GPR109 Monoclonal Antibody (4NZBRGO), Alexa Fluor™ 647, eBioscience™, Invitrogen™
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Product Code. 15825463
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15825463 100 Tests Pack of 100
15815463 25 Tests Pack of 25
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Product Code. 15825463 Supplier Invitrogen™ Supplier No. 51477942

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Description

Mouse Monoclonal Antibody

This 4NZBRGO antibody has not been tested for reactivity with human GPR109B. Applications Reported: This 4NZBRGO antibody has been reported for use in flow cytometric analysis. Applications Tested: This 4NZBRGO antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

GPR109A (also known as HCA2, HM74a, and NIACR1) is a 42kDa G-protein coupled receptor that belongs to a family of three hydroxyl-carboxylic acid receptors, which also include GPR109B and GPR81. GPR109A has two known ligands: niacin and butyrate (or its derivative 3-hydroxybutyrate). The endogenous ligands for GPR109B and GPR81 are 3-hydroxyl-octanoic acid and 2-hydroxy-propanoate (lactate), respectively. GPR109A is expressed on adipocytes, neutrophils, Langerhans cells, keratinocytes, intestinal epithelial cells, and intestinal colonic macrophages. Niacin, also known as nicotinic acid or vitamin B3, is known to improve cholesterol metabolism (LDL/HDL ratio) and reduce inflammation. It has been demonstrated that this effect is mediated through GPR109A. Notably, GPR109A also has an essential role in suppressing inflammation and cancer in the colon. Both GPR109A ligands are produced by colonic commensal bacteria. In mice, GPR109A expression on intestinal epithelial cells and DCs/macrophages contributes to the suppression of colitis and colon cancer. In humans, GPR109A is silenced in colon carcinoma cells by DNA methylation, which increases inflammation in the intestinal tract.
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Specifications

Antigen GPR109
Applications Flow Cytometry
Classification Monoclonal
Clone 4NZBRGO
Concentration 5 μL/Test
Conjugate Alexa Fluor 647
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene HCAR2
Gene Accession No. Q8TDS4
Gene Alias G protein-coupled receptor 109A; G protein-coupled receptor 109B; G protein-coupled receptor HM74a; Gpr109; Gpr109a; Gpr109b; G-protein coupled receptor 109; G-protein coupled receptor 109A; G-protein coupled receptor HM74; G-protein coupled receptor HM74A; HCA2; Hcar2; HM74; HM74a; HM74b; hydroxycarboxylic acid receptor 2; hydroxy-carboxylic acid receptor 2; interferon-gamma inducible gene, Puma-g; mHM74b; Niacin receptor 1; Niacr1; Nicotinic acid receptor; Protein PUMA-G; PUMAG; PUMA-G; PUMA-G. GPR109; putative seven transmembrane spanning receptor
Gene Symbols HCAR2
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 338442
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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