gpnmb Rat anti-Mouse, eFluor 660, Clone: CTSREVL, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 50-5708-80
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionThis CTSREVL monoclonal antibody recognizes human GPNMB also known as Osteoactivin, DC-HIL and HGFIN. This type-1 transmembrane glycoprotein was described independently as a bone development factor, tumor related molecule, neurokinin, and immune regulator. Expressed on macrophages and dendritic cells, GPNMB is a ligand for proteoglycan Syndecan-4 (SD-4), which is found on T cells and is known to inhibit their activation and proliferation. Hence, surface expression of GPNMB by myeloid cells may be indicative of their tolerogenic properties. Various cancers express GPNMB, and it is suspected to help in immune evasion. Treatment with IL-10 and various immunosuppressive drugs (e.g., dexamethasone) upregulate GPNMB on macrophages and dendritic cells. GPNMB may also be secreted.
The CTSREVL antibody will work on paraformaldehyde-fixed cells.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
|Osteoactivin, DC-HIL, HGFIN|