gpnmb Rat anti-Mouse, eFluor 660, Clone: CTSREVL, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-5708-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15579976

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Quantity 25μg
Regulatory Status RUO
Format Conjugated
Clone CTSREVL
Conjugate eFluor 660
Concentration 0.2mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Gene Alias Osteoactivin, DC-HIL, HGFIN
Isotype IgG2a
Host Species Rat
Antigen gpnmb

This CTSREVL monoclonal antibody recognizes human GPNMB also known as Osteoactivin, DC-HIL and HGFIN. This type-1 transmembrane glycoprotein was described independently as a bone development factor, tumor related molecule, neurokinin, and immune regulator. Expressed on macrophages and dendritic cells, GPNMB is a ligand for proteoglycan Syndecan-4 (SD-4), which is found on T cells and is known to inhibit their activation and proliferation. Hence, surface expression of GPNMB by myeloid cells may be indicative of their tolerogenic properties. Various cancers express GPNMB, and it is suspected to help in immune evasion. Treatment with IL-10 and various immunosuppressive drugs (e.g., dexamethasone) upregulate GPNMB on macrophages and dendritic cells. GPNMB may also be secreted.

The CTSREVL antibody will work on paraformaldehyde-fixed cells.