Invitrogen™ GPI Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA589153

Product Code. 16517161

Description

Immunogen sequence: MAALTRDPQF QKLQQWYREH RSELNLRRLF DANKDRFNHF SLTLNTNHGH ILVDYSKNLV TEDVMRMLVD LAKSRGVEAA RERMFNGEKI NYTEGRAVLH VALRNRSNTP ILVDGKDVMP EVNKVLDKMK SFCQRVRSGD WKGYTGKTIT DVINIGIGGS DLGPLMVTEA LKPYSSGGPR VWYVSNIDGT HIAKTLAQLN PESSLFIIAS KTFTTQETIT NAETAKEWFL QAAKDPSAVA KHFVALSTNT TKVKEFGIDP QNMFEFWDWV GGRYSLWSAI; Positive Samples: HL-60, BT-474, MCF7, HeLa, Mouse kidney, Mouse heart, Mouse brain, Rat brain, Rat heart; Cellular Location: Cytoplasm.

This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

Specifications

• Antigen: GPI
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPI
• Gene Alias: Amf; Autocrine motility factor; glucose phosphate isomerase; glucose phosphate isomerase 1; glucose phosphate isomerase 1 complex; glucose phosphate isomerase 1, regulatory; glucose phosphate isomerase 1, structural; glucose phosphate isomerase 1, temporal; glucose-6-phosphate isomerase; glucose-6-phosphate isomerase {ECO:0000250; GNPI; Gpi; GPI {ECO:0000250; gpi {ECO:0000312; GPI1; Gpi-1; Gpi-1r; Gpi1-r; Gpi1s; Gpi-1s; Gpi1-s; Gpi-1t; Gpi1-t; GPI-GlcNAc transferase complex subunit GPI1; hexose monophosphate isomerase; hexosephosphate isomerase; maturation factor; MF; Neuroleukin; neuroleukin {ECO:0000250; NK; NK/GPI; Nlk; NLK {ECO:0000250; Org; oxoisomerase; PGI; PGI {ECO:0000250; Phi; PHI {ECO:0000250; phosphatidylinositol N-acetylglucosaminyltransferase; Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1; Phosphoglucose isomerase; phosphoglucose isomerase {ECO:0000250; phosphohexomutase; phosphohexose isomerase; phosphohexose isomerase {ECO:0000250; phosphosaccharomutase; RGD:2727}; SA36; SA-36; sperm antigen; sperm antigen 36; sperm antigen-36; UniProtKB:P06745}; YGR216C
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14751, 2821, 292804
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.8 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P06744, P06745, Q6P6V0
• Gene Symbols: GPI, Gpi1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human glucose-6-phosphate isomerase (NP_0001662).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG