DAG1, Goat, Polyclonal Antibody, Abnova™

Goat polyclonal antibody raised against synthetic peptide of DAG1.

Brand:  Abnova PAB18550.100ug

Product Code. 16083157

Description

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants

Sequence: C-HVGKHEYFMHATDK

Specifications

• Antigen: DAG1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:128000) Western Blot (0.2-0.6 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: DAG1
• Gene Alias: 156DAG/A3a/AGRNR/DAG
• Host Species: Goat
• Purification Method: Antigen affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 1605
• Target Species: Human
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.5 mg/mL
• Description: Goat polyclonal antibody raised against synthetic peptide of DAG1.
• Formulation: In 0.5mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
• Gene Accession No.: NP_004384.3
• Gene Symbols: DAG1
• Immunogen: A synthetic peptide corresponding to amino acids at internal region of human DAG1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: Reported variants represent identical protein: NP_001159400.1, NP_004384.3.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only