COMT Goat anti-Human, Polyclonal Antibody, Abnova™

Goat polyclonal antibody raised against synthetic peptide of COMT.

Brand:  Abnova PAB7078.100ug

Product Code. 16010198

Description

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq

Sequence: C-QDIIPQLKKKYDVD

Specifications

• Antigen: COMT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:64000) Sandwich ELISA (0.5-2 ug/mL) Western Blot (0.03-0.1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: COMT
• Gene Symbols: COMT
• Immunogen: A synthetic peptide corresponding to internal region of human COMT.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody is expected to recognize both reported isoforms (NP_000745.1 and NP_009294.1).
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Western Blot
• Concentration: 0.5 mg/mL
• Description: Goat polyclonal antibody raised against synthetic peptide of COMT.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene Accession No.: NP_000745.1;NP_009294.1
• Host Species: Goat
• Purification Method: Antigen affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 1312
• Target Species: Human
• Form: Liquid

For Research Use Only