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  5. Tocris Bioscience™ GNF 7

Tocris Bioscience™ GNF 7
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Product Code. p-7110969
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18743979

Brand: Tocris Bioscience™ 5607/10

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Description

Ras signaling inhibitor; inhibits Ack1 and GCK

GNF 7 is a potent Bcr-Abl inhibitor (IC50 values are 61 and 133 nM for T315I and wild-type Bcr-Abl, respectively), inhibiting a range of clinically relevant Bcr-Abl mutants such as T315I, G250E, E255V, F317L and M351T. GNF 7 is also a Ras signaling inhibitor as well as inhibiting Ack1 and germinal center kinase (GCK). GNF 7 induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations, and shows growth inhibitory activity in human colon cancer cells. It prolongs survival in a leukemia cell xenotransplantation model in mice and is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material Ras GTPase Inhibitors
CAS 839706-07-9
Quantity 10 mg
Target Small G Protein Inhibitors
Molecular Formula C28H24F3N7O2
Formula Weight 547.53
Purity >98%
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