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GNE-781, MedChemExpress

Product Code. 16475166
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Product Code. 16475166 Supplier Medchem Express Supplier No. HY108696

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Description

MedChemExpress GNE-781 is an orally active, highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model.

GNE-781 is an orally active, highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model.

Specifications

Chemical Name or Material GNE-781
Physical Form Solid
CAS 1936422-33-1
Color Yellow
Quantity 100 mg
Purity Grade Notes Research
Molecular Formula C27H33F2N7O2
For Use With (Application) Cancer-programmed cell death
Solubility Information DMSO : 100 mg/mL (190.26 mM; Need ultrasonic)
SMILES O=C(N1CCC(N(C2CCOCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)NC
Molecular Weight (g/mol) 525.59
Formula Weight 525.59
Percent Purity 98.19%
Grade Research
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Research purposes only

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