Invitrogen™ GNAO1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA559337

Product Code. 15797191

Description

Immunogen sequence: IQSLAAIVRA MDTLGIEYGD KERKADAKMV CDVVSRMEDT EPFSAELLSA MMRLWGDSGI QECF Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 97%.

Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.

Specifications

• Antigen: GNAO1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GNAO1
• Gene Alias: alphaO; AW050213; DKFZp686O0962; EIEE17; G alpha o; G protein subunit alpha o1; Galphao; G-ALPHA-o; Gna0; Gnao; GNAO 1; Gnao1; Go alpha; GO2-q chimeric G-protein; GTP-binding protein alpha o; GTP-binding protein alpha-o subunit; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha O; guanine nucleotide binding protein, alpha O polypeptide 1; guanine nucleotide-binding protein G(o) subunit alpha; guanine nucleotide-binding regulatory protein 2; HLA-DQB1; RATBPGTPC
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2775
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P09471
• Gene Symbols: GNAO1
• Immunogen: Recombinant protein corresponding to Human GNAO1. Recombinant protein control fragment (Product #RP-102901).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG