Invitrogen™ Glutamine Synthetase Monoclonal Antibody (CL2999)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA535005

Product Code. 17135673

Description

Immunogen sequence: LQSEGSNSDM YLVPAAMFRD PFRKDPNKLV LCEVFKYNRR PAETNLRHTC KRIMDMVSNQ HPWFGMEQEY TLMGTDGHPF GWPSNGFPGP QGPYYCGVGA DRAYGRDIVE AHYRACLYAG VKIAGTNAEV MPAQWEFQIG P.

Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation.

Specifications

• Antigen: Glutamine Synthetase
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: GLUL
• Gene Alias: cell proliferation-inducing protein 59; GLNA; GLNS; Glul; GLUL protein; Glutamate ammonia ligase; glutamate decarboxylase; glutamate-ammonia ligase; glutamate--ammonia ligase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase (glutamine synthetase); glutamine synthase; glutamine synthetase; Glutamine synthetase (glutamate-ammonia ligase); glutamine synthetase 1; glutamine synthetase I; GS; Palmitoyltransferase GLUL; PIG43; PIG59; Proliferation inducing protein 43; proliferation-inducing protein 43
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 14645, 24957, 2752
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: CL2999
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P09606, P15104, P15105
• Gene Symbols: GLUL
• Immunogen: Recombinant Protein corresonding to Human Glutamine Synthetase.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1