Glimepiride, Thermo Scientific™

Product Code	Brand	Quantity
15484489	Thermo Scientific Alfa Aesar J62032.MC	100mg
15474489	Thermo Scientific Alfa Aesar J62032.03	1g

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Solubility
Soluble in DMSO

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Chemical Identifiers

• CAS: 93479-97-1
• Molecular Weight (g/mol): 490.62
• InChI Key: WIGIZIANZCJQQY-UHFFFAOYSA-N
• PubChem CID: 3476
• SMILES: CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC2CCC(C)CC2)C1=O

• Molecular Formula: C24H34N4O5S
• MDL Number: MFCD00878417
• Synonym: glimepiride, amaryl, glimepiridum, glimepirida, amarel, glimepirid, glimepride, endial, roname, glimepiridum latin
• IUPAC Name: 3-ethyl-4-methyl-N-{2-[4-({[(4-methylcyclohexyl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Specifications

• CAS: 93479-97-1
• MDL Number: MFCD00878417
• Synonym: glimepiride, amaryl, glimepiridum, glimepirida, amarel, glimepirid, glimepride, endial, roname, glimepiridum latin
• InChI Key: WIGIZIANZCJQQY-UHFFFAOYSA-N
• IUPAC Name: 3-ethyl-4-methyl-N-{2-[4-({[(4-methylcyclohexyl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
• PubChem CID: 3476
• Chemical Name or Material: Glimepiride

• Molecular Formula: C24H34N4O5S
• Merck Index: 14,4440
• Solubility Information: Soluble in DMSO
• SMILES: CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC2CCC(C)CC2)C1=O
• Molecular Weight (g/mol): 490.62
• Formula Weight: 490.62

Safety and Handling

missing translation for 'rtecsNumber' : UX9363950

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

RUO – Research Use Only