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GFAP, clone: GA5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9892-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15288207

  • £49.97 / 25µg


EU Stock 2
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Description

Description

Description: This GA5 monoclonal antibody reacts with human, mouse, rat, chicken, rabbit, and pig glial fibrillary acidic protein (GFAP). This 49-kDa type III intermediate filament protein is expressed in neural tissues and distinguishes astrocytes from other glial cells during central nervous system development. Three alternative splice variants of GFAP exist; however, alpha-GFAP is the predominant form expressed in astrocytes. GFAP can co-assemble with vimentin and nestin in astrocytes, but such associations are not required for assembly. Like other intermediate filaments, GFAP assembly is dependent on phosphorylation and dephosphorylation of the N-terminal domain. Studies have demonstrated that mutations in the GFAP gene lead to Alexander disease. Moreover, GFAP has also been shown to be overexpressed in certain glial-derived tumors.Applications Reported: This GA5 antibody has been reported for use in immunocytochemistry, western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and flow cytometric analysis.Applications Tested: This GA5 antibody has been tested by immunoblotting of lysate prepared from mouse brain, immunocytochemistry of fixed and permeabilized C6 cells, and immunohistochemistry of FFPE human tissue using low pH antigen retrieval. This can be used at less than or equal to 5 μg/mL.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Glial Fibrillary Acid Protein (GFAP)
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P14136, P03995, P47819
GFAP, FLJ45472
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Rat
Western Blot
GA5
Unconjugated
GFAP
Purified
GFAP
IgG1
25μg
Store at 2-8°C.
Primary
2670
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