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Glial Fibrillary Acid Protein (GFAP) Mouse, Alexa Fluor 488, Clone: GA5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-9892-80

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15342090

  • £72.77 / 25µg


EU Stock 3
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Disclaimers:

For Research Use Only.


Description

Description

This GA5 monoclonal antibody reacts with human, mouse, rat, chicken, rabbit, and pig glial fibrillary acidic protein (GFAP). This 49kDa type III intermediate filament protein is expressed in neural tissues and distinguishes astrocytes from other glial cells during central nervous system development. Three alternative splice variants of GFAP exist; however, α-GFAP is the predominant form expressed in astrocytes. GFAP can co-assemble with vimentin and nestin in astrocytes, but such associations are not required for assembly. Like other intermediate filaments, GFAP assembly is dependent on phosphorylation and dephosphorylation of the N-terminal domain. Studies have demonstrated that mutations in the GFAP gene lead to Alexander disease. Moreover, GFAP has also been shown to be overexpressed in certain glial-derived tumors.
Specifications

Specifications

Glial Fibrillary Acid Protein (GFAP)
GA5
Alexa Fluor™ 488
Conjugated
IgG1
RUO
Primary
Rat
Microscopy
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal