GILZ Rat anti-Mouse, Clone: CFMKG15, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-4033-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15297347

Quantity Price
1 £ 152.25 / 100µg
Estimated Shipment date
from Supplier 08-05-2017
Add to basket


Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Gene Alias Glucocorticoid-Induced Leucine Zipper, TSC22D3
Clone CFMKG15
Regulatory Status RUO
Antigen GILZ
Format Purified
Host Species Rat
Applications Flow Cytometry (Intracellular Staining)
Applications Immunocytochemistry
Applications Western Blotting
Conjugate Unlabeled
Isotype IgG2a
Primary or Secondary Primary
Storage Requirements Store at 2-8°C.
Species Reactivity Mouse
Concentration 0.5mg/mL
Quantity 100μg

GILZ is a leucine-zipper-containing protein that is induced by glucocorticoids. It is expressed in mast cells, monocytes, macrophages, dendritic cells, and T cells. GILZ has been shown to inhibit production of IL-2 as well as TCR-driven upregulation of FasL. GILZ mediates these changes in transcription, at least in part, by inhibiting DNA-binding of the transcription factors AP-1 and NF-κB. GILZ has also been shown to mediate anti-inflammatory signals in macrophages and dendritic cells by interfering with NF-κB-mediated signaling. Although GILZ has been reported to localize to the nucleus, more recent reports as well as testing at eBioscience have observed predominantly cytoplasmic staining.