Gibco™ Human Flt-3 Ligand (FLT3L) Recombinant Protein

Product Code. 10631120

Brand: Gibco™ PHC9415

Description

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water or appropriate buffered solution containing 0.1% BSA to regain full activity. Apportion there constituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in buffered solution containing a carrier protein, such as PBS + 0.1% BSA. Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C. Avoid repeated freeze-thaw cycles.

FLT3LG (Fms Related Tyrosine Kinase 3 Ligand) is a Protein Coding gene. Diseases associated with FLT3LG include Aplastic Anemia and Brain Cancer. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cytokine activity. Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8-positive classical DCs and their CD103-positive tissue counterparts.

Specifications

• Accession Number: P49771
• For Use With (Application): Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 2323
• Molecular Weight (g/mol): 35 kDa
• Name: Human Flt-3 Ligand (FLT3L)
• Purification Method: Purified
• Quantity: 25 μg
• Storage Requirements: 4°C
• Regulatory Status: RUO
• Endotoxin Concentration: <0.1 ng/μg
• Gene Alias: FL; Flt 3 ligand; Flt3; Flt3 L; Flt3 ligand; Flt3l; Flt3lg; fms related receptor tyrosine kinase 3 ligand; fms related tyrosine kinase 3 ligand; FMS-like tyrosine kinase 3 ligand; fms-related tyrosine kinase 3; fms-related tyrosine kinase 3 ligand; H-FLT-3-L; Ly72L; M-FLT-3-L; NEWGENE_2322792; SL cytokine
• Common Name: FLT3LG
• Gene Symbol: FLT3LG
• Biological Activity: ED50 ≤ 5 ng/mL; determined by the dose-dependent proliferation of human OCI-AML5 cells.
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Sequence: TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTAPQP
• Content And Storage: 4°C
• Classification: Carrier-Free
• Activity: ED50 ≤ 5 ng/mL; determined by the dose-dependent proliferation of human OCI-AML5 cells.
• Endotoxin Level: <0.1 ng/μg
• Reactivity: Human
• Shipping Condition: Wet Ice
• Expression System: HEK293 cells
• Protein Family: Growth Factors & Receptors
• Protein Form: Recombinant, Ligand
• Form: Lyophilized
• Protein Subtype: FLT-3 Ligand
• Research Category: Signal Transduction, Stem Cell Research, Oncology
• Product Line: Gibco
• Purity or Quality Grade: >95% by SDS-PAGE