Invitrogen™ GFI1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA577985

Product Code. 16346694

Description

Positive Control: THP-1, HL-60 Predicted Reactivity: Mouse (80%), Rat (81%), Dog (87%), Cat (89%), Rhesus Monkey (98%), Bovine (88%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

GFI1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The Gfi1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of Gfi-1 causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome in mice.

Specifications

• Antigen: GFI1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GFI1
• Gene Alias: AW495828; FLJ94509; Gfi1; GFI-1; GFI1A; growth factor independence-1; growth factor independent 1; growth factor independent 1 transcription repressor; growth factor independent 1 transcriptional repressor; growth factor independent protein 1; Growth factor independent-1; Pal1; Pal-1; SCN2; Zinc finger protein 163; zinc finger protein Gfi-1; ZNF163
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2672
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1.49 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q99684
• Gene Symbols: GFI1
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human GFI1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG