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  6. Invitrogen™ GEN1 Recombinant Rabbit Monoclonal Antibody (K01_1R62)

Invitrogen™ GEN1 Recombinant Rabbit Monoclonal Antibody (K01_1R62)
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Product Code. 30826219
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30826219 100 μL
30828163 50 μL
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Product Code. 30826219 Supplier Invitrogen™ Supplier No. MA563453

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Description

Rabbit Recombinant Monoclonal Antibody

GEN1 Recombinant Monoclonal Antibody for Western Blot

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GEN1
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_1R62
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 150mM NaCl, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene GEN1
Gene Accession No. Q17RS7, Q8BMI4
Gene Alias 5830483C08Rik; Flap endonuclease GEN homolog 1; Gen; Gen endonuclease homolog 1; Gen homolog 1, endonuclease; Gen homolog 1, endonuclease (Drosophila); GEN1; GEN1 Holliday junction 5' flap endonuclease; GEN1, Holliday junction 5' flap endonuclease; Holliday junction resolvase; RGD1559792
Gene Symbols GEN1
Host Species Rabbit
Immunogen A synthetic peptide of human GEN1.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 209334, 298884, 348654
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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