Invitrogen™ GEMIN8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA555920

Product Code. 15793831

Description

Immunogen sequence: ASTSKATRPW YSHPVYARYW QHYHQAMAWM QSHHNAYRKA VESCFNLPWY LPSALLPQSS YDNEAAYPQS FYDHHVAWQD YPCSSSHFRR SGQHPRYSSR IQASTKEDQA LSKEEEMETE SDAEVECDLS NMEITEELRQ YFAETER Highest antigen sequence identity to the following orthologs: Mouse - 59%, Rat - 60%.

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Specifications

• Antigen: GEMIN8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GEMIN8
• Gene Alias: B130034M20Rik; B930082C09Rik; BC023488; Fam51a1; family with sequence similarity 51, member A1; family with sequence similarity 51, member A1 homolog; gem (nuclear organelle) associated protein 8; gem nuclear organelle associated protein 8; gem-associated protein 8; GEMIN8; Gemin-8; Protein FAM51A1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54960
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NWZ8
• Gene Symbols: GEMIN8
• Immunogen: Recombinant protein corresponding to Human GEMIN8. Recombinant protein control fragment (Product #RP-92173).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG