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Invitrogen™ GEMC1 Polyclonal Antibody

Product Code. 12839302
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12839302 100 μg 100µg
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Product Code. 12839302 Supplier Invitrogen™ Supplier No. PA521158

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse heart tissue lysate. PA5-21158 can be used with blocking peptide PEP-1272.

The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GEMC1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene GMNC
Gene Accession No. A6NCL1, Q3URY2
Gene Alias GEMC1; geminin coiled-coil domain containing; geminin coiled-coil domain-containing protein 1; Gm1778; Gm606; GMNC
Gene Symbols GMNC
Host Species Rabbit
Immunogen A 19 amino acid peptide near the center of human GEMC1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 239789, 647309
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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