STEMCELL Technologies Geldanamycin

Product Code. 17140312

Brand: STEMCELL Technologies 74032

Description

Inhibits Hsp90

• Geldanamycin is a benzoquinone ansamycin antibiotic that selectively inhibits heat shock protein 90 (Hsp90) (Schulte et al.; Whitesell et al.) It inhibits the ATPase activity of Hsp90 by binding with high affinity to the N-terminal ATP-binding site (Kd = 1.2 μM; Roe et al.) Geldanamycin also binds to the glucose-regulated protein GRP94, an endoplasmic reticulum protein with homology to Hsp90
• This interaction destabilizes its complex with p185-ERBB2 leading to degradation of ERBB2 protein, which is overexpressed in aggressive breast cancers (Chavany et al.; Castagnola et al.)
• Inhibits growth of 60 human tumor cell lines (Supko et al.)
• Regulates innate immune response as demonstrated by inhibition of inflammasome activity in a mouse gout model (Mayor et al.)
• Inhibits replication of HSV-1 and HSV-2 (Li et al.)

Specifications

• CAS: 30562-34-6
• Synonym: NSC 122750
• Quantity: 1 mg
• Molecular Formula: C₂₉H₄₀N₂O₉
• Purity: ≥98%