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Gefitinib hydrochloride, MedChemExpress

Product Code. 16497886
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Quantity:
100 mg
500 mg
1 g
5 g
Unit Size:
100mg
1g
500mg
5g
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Product Code. 16497886

Brand: Medchem Express HY50895A

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Description

MedChemExpress Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity.

Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity.

Specifications

Chemical Name or Material Gefitinib hydrochloride
CAS 184475-55-6
Color Off-White
Purity Grade Notes Research
Molecular Formula C22H25Cl2FN4O3
Quantity 100 mg
Synonym ZD-1839 hydrochloride
Solubility Information H2O : 6.25 mg/mL (12.93 mM; Need ultrasonic) ∣DMSO : 0.227 mg/mL (0.47 mM; Need ultrasonic and warming)
SMILES ClC1=C(C=CC(NC2=NC=NC3=C2C=C(C(OC)=C3)OCCCN4CCOCC4)=C1)F.[H]Cl
Molecular Weight (g/mol) 483.36
Formula Weight 483.36
Percent Purity 99.8%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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