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Gefitinib-based PROTAC 3, MedChemExpress

Product Code. 16467857
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Product Code. 16467857 Supplier Medchem Express Supplier No. HY123921

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Description

MedChemExpress Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.

Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.

Specifications

Chemical Name or Material Gefitinib-based PROTAC 3
CAS 2230821-27-7
Color White
Purity Grade Notes Research
Molecular Formula C47H57ClFN7O8S
Quantity 5 mg
Solubility Information DMSO : ≥ 60 mg/mL (64.20 mM)
SMILES O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Molecular Weight (g/mol) 934.51
Formula Weight 934.51
Percent Purity 98.24%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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